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卢旷达



联系电话:18211026017
电子邮箱:lukuangda@hsc.pku.edu.cn
个人主页:



教育经历:

2016.8 芝加哥大学 化学博士 (The University of Chicago, Ph.D. in Chemistry)

2011.6 北京大学 元培学院化学方向 理学学士 (Peking University, B.S.)


学术简历 :

2018.9 至今 北京大学跨学部生物医学工程系助理教授,副研究员 (Assistant Professor in Biomedical Engineering Department, Peking University) 
2016.9-2018.9 芝加哥大学肿瘤放射中心与化学系,博士后 (Postdoctoral Scholar in The University of Chicago, Department of Radiation Oncology and Department of Chemistry)


研究领域:

生物材料(Biomaterials),纳米医药学(Nanomedicine),肿瘤生物学(Cancer Biology),放射肿瘤医学(Radiation Oncology)


教授课程


研究内容:


研究主要涉及纳米材料在生物医学上的应用,研究方向包括(1)基于纳米材料的肿瘤联合治疗,包括化学疗法、光动力疗法、放射疗法、基因疗法、免疫疗法等;(2)基于纳米复合材料的新型肿瘤放射治疗方法及其机理研究;(3)生物纳米探针材料的开发等。


获得荣誉:

American Chemical Society Division of Inorganic Chemistry Young Investigator Award  (2017)
American Chemical Society Yao Yuan Award of Medicinal Chemistry, Second Place (2017)
The Elizabeth R. Norton Prize for Excellence in Research in Chemistry at the University of Chicago (2016)
Kharasch Travel Award for Postdoctoral Scholars at the University of Chicago (2016)
Weil Endowed Fellowship Fund at the University of Chicago (2015)


主要论文列表(最近5年):

  1. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Lan, G.; Tang, H.; Pelizzari, C.; Fu, Y.-X.; Weichselbaum, R. R.; Lin, W. Low-dose X-ray Radiotherapy-Radiodynamic Therapy via Nanoscale Metal-Organic Frameworks Enhances Checkpoint Blockade Immunotherapy. Nat. Biomed. Eng. 2018, 2, 600-610
  2. Lu, K.; Aung, T.; Guo, N.; Weichselbaum, R. R.; Lin, W. Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. Adv. Mater. 2018, 30 (37), 1707634
  3. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Weichselbaum, R. R.; Lin, W. Chlorin-Based Nanoscale Metal?Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J. Am. Chem. Soc. 2016, 138 (38), 12502-12510
  4. Lu, K.; He, C.; Lin, W. A Chlorin-Based Nanoscale Metal?Organic Framework for Photodynamic Therapy of Colon Cancers. J. Am. Chem. Soc. 2015, 137 (24), 7600-7603
  5. Lu, K.; He, C.; Lin, W. Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer. J. Am. Chem. Soc. 2014, 136 (48), 16712-16715
  6. He, C.; Lu, K.; Lin, W. Nanoscale Metal–Organic Frameworks for Real-Time Intracellular pH Sensing in Live Cells. J. Am. Chem. Soc. 2014, 136 (35), 12253-12256 (Co-First Author)
  7. He, C.; Lu, K.; Liu, D.; Lin, W. Nanoscale Metal–Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells. J. Am. Chem. Soc. 2014, 136 (14), 5181-5184
  8. Liu, D.; Lu, K.; Poon, C.; Lin, W. Metal–Organic Frameworks as Sensory Materials and Imaging Agents. Inorg. Chem. 2013, 53 (4), 1916-1924
  9. Liu, D.; Poon, C.; Lu, K.; He, C.; Lin, W. Self-assembled Nanoscale Coordination Polymers with Trigger Release Properties for Effective Anticancer Therapy. Nat. Comm. 2014, 5, 4182
  10. Ni, K.; Lan, G.; Chan, C.; Quigley, B.; Lu, K.; Aung, T.; Guo, N.; La Riviere, P.; Weichselbaum, R. R.; Lin, W. Nanoscale Metal-Organic Frameworks Enhance Radiotherapy to Potentiate Checkpoint Blockade Immunotherapy. Nat. Comm. 2018, 9, 2351
  11. Lan, G.; Ni, K.; Xu, R.; Lu, K.; Lin, Z.; Chan, C.; Lin, W. Nanoscale Metal–Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy. Angew. Chem. Int. Ed. 2017, 56, 1-6
  12. Xu, R.; Wang, Y.; Duan, X.; Lu, K.; Micheroni, D.; Hu, A.; Lin, W. Nanoscale Metal–Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells. J. Am. Chem. Soc. 2016, 138(7), 2158-2161
  13. Dai, R.; Peng, F.; Ji, P.; Lu, K.; Wang, C.; Sun, J.; Lin, W. Electron Crystallography Reveals Atomic Structures of Metal–Organic Nanoplates with M123-O)83-OH)82-OH)6(M=Zr, Hf) Secondary Building Units. Inorg. Chem. 2017, 56 (14), 8128-8134
  14. Poon, C.; He, C.; Liu, D.; Lu, K.; Lin, W. Self-assembled Nanoscale Coordination Polymers Carrying Oxaliplatin and Gemcitabine for Synergistic Combination Therapy of Pancreatic Cancer. J. Control. Release. 2015, 201, 90-99
  15. Wang, C.; Volotskova, O.; Lu, K.; Ahmad, M.; Sun, C.; Xing, L.; Lin, W. Synergistic Assembly of Heavy Metal Clusters and Luminescent Organic Bridging Ligands in Metal–Organic Frameworks for Highly Efficient X-ray Scintillation. J. Am. Chem. Soc. 2014, 136 (17), 6171-6174
  16. Abney, C.W.; Gilhula, J. C.; Lu, K.; Lin, W. Metal-Organic Framework Templated Inorganic Sorbents for Rapid and Efficient Extraction of Heavy Metals. Adv. Mater. 2014, 26, 7993–7997

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